3 posts tagged with "sumstats"

We have recently updated our summary statistic schema and our heritability estimates:

1. We have identified a bug in the computation of heritability point estimates involving use of improper allele frequencies. We have resolved the issue and accordingly recomputed all biobank-wide heritability analyses using all methods. These updated results can be found in the updated manifests.
2. With new heritability estimates, we have now recomputed QC for all summary statistics. This has resulted in a largely overlapping (but non-identical) set of 1091 QC-pass phenotype-ancestry pairs, with this new set used for QC-pass meta-analysis. Per-phenotype, per-ancestry association statistics remain identical.
3. We have recomputed the maximally independent set using the same approach as described previously, now incorporating the updated set of QC-pass phenotypes.
4. We have updated our summary statistics schema to now include clearly labeled -log10 p-values rather than ln p-values as previous. More information on the updated schema can be found on the per-phenotype files page. Archived summary statistics using the previous schema can be found at updated paths listed in the archived sheet of the phenotype manifest.

These changes should help improve the clarity and quality of our released data.

We have recently updated our summary statistic schema and our heritability estimates:

1. We have identified a bug in the computation of heritability point estimates involving use of improper allele frequencies. We have resolved the issue and accordingly recomputed all biobank-wide heritability analyses using all methods. These updated results can be found in the updated manifests.
2. With new heritability estimates, we have now recomputed QC for all summary statistics. This has resulted in a largely overlapping (but non-identical) set of 1091 QC-pass phenotype-ancestry pairs, with this new set used for QC-pass meta-analysis. Per-phenotype, per-ancestry association statistics remain identical.
3. We have recomputed the maximally independent set using the same approach as described previously, now incorporating the updated set of QC-pass phenotypes.
4. We have updated our summary statistics schema to now include clearly labeled -log10 p-values rather than ln p-values as previous. More information on the updated schema can be found on the per-phenotype files page. Archived summary statistics using the previous schema can be found at updated paths listed in the archived sheet of the phenotype manifest.

These changes should help improve the clarity and quality of our released data.

We are excited to report significant updates to our summary statistics and data release:

1. We performed heritability analyses across > 16,000 ancestry-trait pairs using several approaches.
2. We developed a detailed summary statistics QC approach to prioritize the highest-quality phenotypes best suited for downstream analyses.
3. We identified a maximally independent set of phenotypes that passed our QC filters.
4. We recomputed summary statistics for traits that showed extremely significant p-values with standard errors of 0, now with non-zero standard errors and $\log p$-values to avoid numerical underflow.
5. We updated cross-ancestry meta-analyses to incorporate updated summary statistics and also computed new meta-analyses using only QC-pass ancestry-trait pairs.