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Quality control, heritability analyses, and updates to summary statistics

We are excited to report significant updates to our summary statistics and data release:

  1. We performed heritability analyses across > 16,000 ancestry-trait pairs using several approaches.
  2. We developed a detailed summary statistics QC approach to prioritize the highest-quality phenotypes best suited for downstream analyses.
  3. We identified a maximally independent set of phenotypes that passed our QC filters.
  4. We recomputed summary statistics for traits that showed extremely significant p-values with standard errors of 0, now with non-zero standard errors and logโกp\log p-values to avoid numerical underflow.
  5. We updated cross-ancestry meta-analyses to incorporate updated summary statistics and also computed new meta-analyses using only QC-pass ancestry-trait pairs.