We are excited to announce the release of genome-wide LD scores and matrices from the Pan-UK Biobank resource, which contains LD scores for (non-partitioned) LD score regression analysis and full in-sample LD matrices for more extensive analyses such as fine-mapping.
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In this analysis, we aimed to better understand the similarities and differences between imputation-based and sequence-based LD scores. To this end, we compared LD scores from gnomAD (sequence-based) and UKB (imputation-based) across four ancestry groups: African (
AFR), Admixed American (
AMR), East Asian (
EAS), and North-Western European (
NWE in gnomAD). This also serves as a more general comparison between LD scores from two separate cohorts. LD scores were obtained as follows.